NADPH consumption by L-cystine reduction creates a metabolic vulnerability upon glucose deprivation
James H. Joly, Alireza Delfarah, Philip S. Phung, Sydney Parrish, Nicholas Alexander Graham
The paper identifies L-cystine reduction as a metabolic vulnerability in cancer cells under glucose deprivation and proposes co-targeting GLUT1 and glutathione synthesis as a therapeutic strategy.
Journal of Biological Chemistry · Dec 30, 2019Peer-reviewedSystems Biology