James H. Joly

This paper introduces IMaP, a method to analyze tau proteoforms at the single-molecule level, revealing ordered phosphorylation patterns and disease-specific modifications.

This paper introduces DMEA, a method that improves drug repurposing by grouping drugs with shared mechanisms of action, enhancing prioritization and reducing off-target effects.

This paper introduces DGSEA, a method to compare the relative enrichment of two gene sets, showing it outperforms GSEA in capturing metabolic shifts and identifying novel dependencies in cancer cell lines.

The paper identifies L-cystine reduction as a metabolic vulnerability in cancer cells under glucose deprivation and proposes co-targeting GLUT1 and glutathione synthesis as a therapeutic strategy.