Microglial and Astrocyte priming in the APP/PS1 model of Alzheimer’s Disease: increased vulnerability to acute inflammation and cognitive deficits
Ana Belén López-Rodríguez, Edel Hennessy, Carol Murray, Arshed Nazmi, Hugh J. Delaney, Dáire Healy, Steven G. Fagan, Michael D. Rooney, Erika Stewart, Anouchka Jasmine Lewis, Niamh de Barra, Philip Scarry, Louise Riggs‐Miller, Delphine Boche, Mark O. Cunningham, Colm M. Cunningham
This study shows that in the APP/PS1 AD mouse model, microglia and astrocytes are primed to produce exaggerated inflammatory responses to secondary stimuli, leading to cognitive impairments.
Alzheimer s & Dementia · Jun 3, 2021Peer-reviewedNeuroscience