Ana Belén López-Rodríguez

Hyperthermia elevates brain temperature and improves behavioural signs in animal models of Autism spectrum disorder.

This study shows that elevated body temperature without inflammation improves behavioral signs in two ASD animal models.

Time-dependent dual effect of NLRP3 inflammasome in brain ischemia

This study shows that NLRP3 inhibition after reperfusion reduces brain injury in ischemia by protecting the blood-brain barrier and reducing inflammation.

Microglial and Astrocyte priming in the APP/PS1 model of Alzheimer’s Disease: increased vulnerability to acute inflammation and cognitive deficits

This study shows that in the APP/PS1 AD mouse model, microglia and astrocytes are primed to produce exaggerated inflammatory responses to secondary stimuli, leading to cognitive impairments.

TLR4-pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury

This study shows that TLR4-pathway activation in astrocytes after TBI leads to synaptic loss and BBB damage, which can be mitigated by TLR4 inhibition.

Acute inflammation alters energy metabolism in mice and humans: Role in sickness-induced hypoactivity, impaired cognition and delirium.

This study investigates how acute inflammation disrupts energy metabolism in mice and humans, linking it to behavioral and cognitive impairments like hypoactivity, delirium, and impaired cognition.