Delphine Boche

This study examines age-related changes in microglia and perivascular macrophages in microcebe primates, finding increased HLA-DR+ expression in white matter and perivascular regions with aging.

This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.

This study investigates the spatial-temporal evolution of extrachromosomal DNA (ecDNA) in glioblastoma, showing that EGFR ecDNA drives tumor evolution and identifies a potential therapeutic window for early intervention.

This study shows that in the APP/PS1 AD mouse model, microglia and astrocytes are primed to produce exaggerated inflammatory responses to secondary stimuli, leading to cognitive impairments.

The paper investigates microglial synaptic internalisation in schizophrenia post-mortem brains and finds no differences in microglial activation or pre-synaptic protein levels between schizophrenia and control cases.

The paper investigates whether human tauopathies are associated with UPR activation and finds no significant changes in UPR markers across tauopathy samples compared to controls.