Author

Mark O. Cunningham

Trinity College DublinORCID 0000-0002-7389-9569Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:differential expression· 5 Research Focus:cell type annotation· 4 Assay:electronic health records· 4 Research Focus:cell-cell communication· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

Alan BeausangiD· 2 shared Amaya Sanz‐Rodriguez· 2 shared Austin Lacey· 2 shared Carol MurrayiD· 2 shared David Clifford HenshalliD· 2 shared Donncha F. O’Brien· 2 shared Francesca M. BrettiD· 2 shared Kieron J. SweeneyiD· 2 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersNeuroscience

Alan BeausangORCID

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Author profile →

7 papers

Recent·Most cited

P2X7 receptor antagonism potentiates seizure-suppressive effects of anti-seizure medications in human resected epileptic brain tissue

Ana Fernandez Martin, Beatriz Gil, Meghma Mitra, Jaideep Kesavan, Austin Lacey, Meng-Juan Sun, Anne Marie O'Callaghan, Vincent Healy, Norman Delanty, Alan Beausang, Francesca M. Brett, Michael A. Farrell, Jane Cryan, Donncha F. O’Brien, Kieron J. Sweeney, , Tobías Engel

This study shows that P2X7R antagonists enhance the effectiveness of anti-seizure medications in human epileptic brain tissue by reducing inflammation and improving drug response.

bioRxiv · Sep 24, 2026 · PreprintNeuroscience

Attenuated single neuron and network hyperexcitability following microRNA-134 inhibition in mice with drug-resistant temporal lobe epilepsy

Pablo Quintana-Sarti, Jordan Higgins, Cristina Ruedell Reschke, Mona Heiland, Amaya Sanz‐Rodriguez, Stephen F. Madden, Mark O. Cunningham, Omar Mamad, David Clifford Henshall

This study shows inhibiting miR-134 reduces single neuron and network hyperexcitability in mice with drug-resistant temporal lobe epilepsy.

Journal of Neuroscience · Feb 10, 2026Peer-reviewedNeuroscience

Inhibitory GABAergic neuron loss due to oxidative damage during ex vivo acute brain slice preparation influences genesis and dynamics of epileptiform activity

Felix Chan, Anupam Hazra, Ashan Jayasekera, Katherine Huang, Shuna Whyte, Leolie Telford‐Cooke, Kamilah Lakhani, Xiaomeng Li, Rebecca Shields, Angeline Kosim, Darwin Su, Carol Murray, Mark O. Cunningham

This study examines how different brain slice preparation methods affect inhibitory GABAergic neuron loss and epileptiform activity in acute brain slices.

Journal of Neurochemistry · Jan 28, 2026Peer-reviewedNeuroscience

MicroRNA inhibition using antimiRs in acute human brain tissue sections

Gareth Morris, Elena Langa, Conor Fearon, Karen Conboy, Kelvin Lau E. How, Amaya Sanz‐Rodriguez, Donncha F. O’Brien, Kieron J. Sweeney, Austin Lacey, Norman Delanty, Alan Beausang, Francesca M. Brett, Jane B. Cryan, Mark O. Cunningham, David Clifford Henshall

This paper demonstrates the effectiveness of antimiR-134 in reducing miR-134 levels in human brain tissue sections, supporting its potential as a treatment for pharmacoresistant epilepsy.

Epilepsia · Jun 3, 2022Peer-reviewedNeuroscience

Microglial and Astrocyte priming in the APP/PS1 model of Alzheimer’s Disease: increased vulnerability to acute inflammation and cognitive deficits

Ana Belén López-Rodríguez, Edel Hennessy, Carol Murray, Arshed Nazmi, Hugh J. Delaney, Dáire Healy, Steven G. Fagan, Michael D. Rooney, Erika Stewart, Anouchka Jasmine Lewis, Niamh de Barra, Philip Scarry, Louise Riggs‐Miller, Delphine Boche, Mark O. Cunningham, Colm M. Cunningham

This study shows that in the APP/PS1 AD mouse model, microglia and astrocytes are primed to produce exaggerated inflammatory responses to secondary stimuli, leading to cognitive impairments.

Alzheimer s & Dementia · Jun 3, 2021Peer-reviewedNeuroscience

Human and Rodent Temporal Lobe Epilepsy is Characterized by Changes in O-GlcNAc Homeostasis that can be Reversed to Dampen Epileptiform Activity

Richard G. Sánchez, R. Ryley Parrish, Megan C. Rich, William M. Webb, Roxanne M. Lockhart, Kazuhito Nakao, Lara Ianov, Susan C. Buckingham, Devin R. Broadwater, Alistair J. Jenkins, Nihal C. de Lanerolle, Mark O. Cunningham, Tore Eid, Kristen Owen Riley, Farah D. Lubin

This study shows that O-GlcNAc homeostasis is disrupted in TLE and that inhibiting OGA can reverse these changes and reduce seizures.

Neurobiology of Disease · Jan 6, 2019Peer-reviewedNeuroscience

Cross-fostering in rodents causes region-specific alterations in entorhinal cortical gamma rhythms associated with NMDA receptor dysfunction

Stephen Hall, Karen Hawkins, Grace C. Laws, Thomas Akitt, Anna Simon, Ceri H. Davies, Miles A. Whittington, Mark O. Cunningham

This paper shows that cross-fostering in rodents disrupts gamma rhythms in the entorhinal cortex, linked to NMDA receptor dysfunction and altered social behavior.

bioRxiv · Apr 11, 2018 · PreprintNeuroscience