Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow onThe Endothelial Cell Transcriptome
Amelia Meecham, Sara McCurdy, Eduardo Frías-Anaya, Wenqing Li, Helios Gallego-Gutiérrez, Phu Ngyuen, Yi-Shuan Julie Li, Shu Chien, John Y.-J. Shyy, Mark H. Ginsberg, Miguel Alejandro Lopez‐Ramirez
This study shows that silencing KRIT1 in endothelial cells under disturbed flow restores KLF2 and KLF4 expression, mimicking the transcriptomic profile of cells under laminar flow.
International Journal of Molecular Sciences · May 2, 2025Peer-reviewedPathology