Author

Sara McCurdy

University of California San DiegoORCID 0000-0001-7854-8808Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Organism:zebrafish· 1

Frequent Co-Authors

Mark H. GinsbergiD· 3 shared Miguel Alejandro Lopez‐RamireziD· 3 shared Amelia MeechamiD· 1 shared Angela Pham· 1 shared Brendan GongoliD· 1 shared Catherine Chinhchu Lai· 1 shared Eduardo Frías-AnayaiD· 1 shared Esau J. EstradaiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersPathology

Mark H. GinsbergORCID

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3 papers

Recent·Most cited

PathologyInternational Journal of Molecular SciencesPeer-reviewedMay 2, 2025

Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow onThe Endothelial Cell Transcriptome

Amelia Meecham, Sara McCurdy, Eduardo Frías-Anaya…·Miguel Alejandro Lopez‐Ramirez

This study shows that silencing KRIT1 in endothelial cells under disturbed flow restores KLF2 and KLF4 expression, mimicking the transcriptomic profile of cells under laminar flow.

3 citations

humanbulk RNA-seq

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Developmental BiologyeLifePeer-reviewedFeb 14, 2025

Genetic Inactivation of the beta1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish

Wenqing Li, Sara McCurdy, Miguel Alejandro Lopez‐Ramirez…·Mark H. Ginsberg

The paper shows that genetic inactivation of the beta1 adrenergic receptor reduces cerebral cavernous malformations in zebrafish, supporting propranolol's therapeutic effect through beta1 receptor antagonism.

DOI 10.7554/elife.99455.3

zebrafishexperimental assay

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NeurosciencebioRxivPreprintJan 29, 2021

Non cell-autonomous effect of astrocytes on cerebral cavernous malformations

Miguel Alejandro Lopez‐Ramirez, Shady Ibrahim Soliman, Preston Hale…·Mark H. Ginsberg

The paper shows that astrocytes contribute to cerebral cavernous malformations (CCMs) through VEGF production driven by endothelial NO, highlighting non-cell-autonomous mechanisms.

2 citations

mouseexperimental assay

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