Author

Shu Chien

University of California San DiegoORCID 0000-0003-0332-285XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:human· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Jie XuiD· 2 shared Sheng ZhongiD· 2 shared Xingzhao WeniD· 2 shared Alex AbrahamiD· 1 shared Alexander D. VeitiD· 1 shared Alexander KukaleviD· 1 shared Amelia MeechamiD· 1 shared Ana PomboiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenomics

Jie XuORCID

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3 papers

Recent·Most cited

GenomicsNaturePeer-reviewedDec 17, 2025

An integrated view of the structure and function of the human 4D nucleome

Job Dekker, Betül Akgöl Oksuz, Yang Zhang…·Feng Yue

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

62 citationstop 1%

humanHi-C

𝕏 PostBluesky

PathologyInternational Journal of Molecular SciencesPeer-reviewedMay 2, 2025

Silencing KRIT1 Partially Reverses the Effects of Disturbed Flow onThe Endothelial Cell Transcriptome

Amelia Meecham, Sara McCurdy, Eduardo Frías-Anaya…·Miguel Alejandro Lopez‐Ramirez

This study shows that silencing KRIT1 in endothelial cells under disturbed flow restores KLF2 and KLF4 expression, mimicking the transcriptomic profile of cells under laminar flow.

3 citations

humanbulk RNA-seq

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GenomicsProceedings of the National Academy of SciencesPeer-reviewedFeb 4, 2019

Genome-wide co-localization of RNA-DNA interactions and fusion RNA pairs

Zhangming Yan, Norman Huang, Weixin Wu…·Sheng Zhong

The paper identifies a correlation between RNA-DNA interactions in normal cells and fusion RNA pairs in cancer, suggesting a mechanism for fusion transcript formation.

75 citations

humanbulk RNA-seq

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