An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2
Rachel E. Miller, Richard J. Miller, Shingo Ishihara, Phuong B. Tran, Suzanne B. Golub, Karena Last, Amanda Fosang, Anne‐Marie Malfait
This study identifies an aggrecan fragment that activates TLR2 on nociceptors, causing pain in osteoarthritis.
JCI Insight · Mar 21, 2018Peer-reviewedNeuroscience