Author

Karena Last

Northwestern UniversityORCID 0000-0002-4396-8404Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1

Frequent Co-Authors

Alexander Charles LewisiD· 1 shared Alexandra M. Birrell· 1 shared Amanda FosangiD· 1 shared Andrew H. WeiiD· 1 shared Ann E. FrazieriD· 1 shared Anne‐Marie MalfaitiD· 1 shared Caitlin L. RoweiD· 1 shared Carlos OpazoiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Alexander Charles LewisORCID

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2 papers

Recent·Most cited

Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukaemia.

Alexander Charles Lewis, Emily Gruber, Rheana L. Franich, Jessica M. Armstrong, Madison J. Kelly, Carlos Opazo, Yau Chung Low, Léa Flippe, Kevin Julio Wijanarko, Caitlin L. Rowe, Celeste Mawal, Alexandra M. Birrell, Joan So, Srimayee Vaidyanathan, Keziah Ting, , Lev M. Kats

This study identifies heme biosynthesis as a selective dependency in AML, showing that its inhibition triggers cuproptosis via copper accumulation and reveals synthetic lethal pathways for therapeutic strategies.

Cell · Nov 19, 2025Peer-reviewedCancer Biology

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Rachel E. Miller, Richard J. Miller, Shingo Ishihara, Phuong B. Tran, Suzanne B. Golub, Karena Last, Amanda Fosang, Anne‐Marie Malfait

This study identifies an aggrecan fragment that activates TLR2 on nociceptors, causing pain in osteoarthritis.

JCI Insight · Mar 21, 2018Peer-reviewedNeuroscience