Anne‐Marie Malfait

This study profiles human cartilage across OA grades, revealing changes in fibronectin expression, splicing, and receptor signaling during disease progression.

The paper uses single-nucleus multiome sequencing to analyze subchondral bone in OA, finding increased osteocyte SMAD2/3 activity and chondrocyte-derived FN1 signaling with disease severity.

The paper shows that B cell-derived IgG in DRG meninges forms tertiary lymphoid structures (TLSs) that drive neuropathic pain after peripheral nerve injury, and disrupting TLSs prevents pain.

The paper identifies A{delta}-HTMRs as fast-conducting mechanonociceptors that drive protective pain responses through unique spinal reflex circuits.

The paper identifies four synovial transcriptional clusters in knee OA linked to cartilage degeneration severity through bulk and single-cell RNA-seq analyses.

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

The paper develops a method combining automated patch clamp and optogenetics to selectively record from specific subtypes of mouse DRG neurons.

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study shows that inhibiting Piezo2 reduces acute inflammatory and osteoarthritis knee pain in mice using FM-dyes.

This study shows that acute systemic macrophage depletion reduces pain-related behaviors in osteoarthritic mice without affecting joint damage.

This paper develops a 3D imaging workflow using clearing-enabled light sheet microscopy to map mouse knee joint innervation and demonstrates changes in nerve density after NGF injection.

This study shows that SHP-1 overexpression reduces capsaicin-induced mechanical allodynia in both male and female mice by dephosphorylating TRPV1 in DRG neurons.

The paper examines nociceptor sprouting in four mouse models of knee OA, finding progressive neuroplasticity associated with joint damage across different stages of the disease.

The paper identifies Mrgprd-expressing DRG neurons as a driver of pain hypersensitivity in a mouse model of PDN and shows targeting these neurons can reverse mechanical allodynia.

This study identifies the cellular distribution of matrisome genes in murine and human dorsal root ganglia, revealing their potential role in neuronal signaling and pain.

This study identifies an aggrecan fragment that activates TLR2 on nociceptors, causing pain in osteoarthritis.

This study uses in vivo calcium imaging to show that DMM surgery increases the number of sensory neurons responding to mechanical stimuli in mice, indicating neuronal sensitization.