Richard J. Miller

This study identifies epidermal Langerhans cells as key contributors to painful diabetic neuropathy, revealing sex-dependent roles in mechanical allodynia and pain behavior.

This study shows that repeated NGF injections into mouse knees cause multiple OA-like features without cartilage damage.

The paper develops a method combining automated patch clamp and optogenetics to selectively record from specific subtypes of mouse DRG neurons.

This study identifies sensory fiber types in mouse TMJ tissues using immunohistochemistry, finding peptidergic fibers dominate with minimal non-peptidergic nociceptors.

This study shows that inhibiting Piezo2 reduces acute inflammatory and osteoarthritis knee pain in mice using FM-dyes.

This paper develops a 3D imaging workflow using clearing-enabled light sheet microscopy to map mouse knee joint innervation and demonstrates changes in nerve density after NGF injection.

This study investigates keratinocyte-derived exosomes in a mouse model of painful diabetic neuropathy, finding differences in their molecular content and showing retrograde trafficking to DRG neurons.

The paper examines nociceptor sprouting in four mouse models of knee OA, finding progressive neuroplasticity associated with joint damage across different stages of the disease.

The paper identifies Mrgprd-expressing DRG neurons as a driver of pain hypersensitivity in a mouse model of PDN and shows targeting these neurons can reverse mechanical allodynia.

This study identifies an aggrecan fragment that activates TLR2 on nociceptors, causing pain in osteoarthritis.

This study uses in vivo calcium imaging to show that DMM surgery increases the number of sensory neurons responding to mechanical stimuli in mice, indicating neuronal sensitization.