Lipid Droplet Targeting Drives Substrate Access during Very Long Chain Fatty Acid Activation by Fat1
Carolin Willner, Jennifer L. Sapia, Bianca M. Esch, Pia Erdbrügger, Lisa Kauffmann, Alicia Damm, Sergej Limar, Sebastian Eising, Stefan Walter, Abdou Rachid Thiam, Carolin Körner, Stefano Vanni, Florian Fröhlich
This study shows lipid droplets are the site of VLCFA activation by Fat1, with Fat1 targeting LDs via an amphipathic helix and using a hydrophobic cavity to access substrates.
bioRxiv · Feb 11, 2026 · PreprintBiochemistry