Matthias Arnold

Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer's disease

The paper identifies preserved mitochondrial bioenergetics in asymptomatic Alzheimer's disease brains and suggests NAD+ precursor interventions could maintain cognitive function despite pathology.

Insights into Renal Protein Handling Through GWAS of the Human Urine Proteome

This study performs GWAS on the human urine proteome, identifying genetic associations with 20 proteins and linking them to disease risk and gene expression.

APOE Genotype Influences on The Brain Metabolome of Aging Mice - Role for Mitochondrial Energetics in Mechanisms of Resilience in APOE2 Genotype.

This study examines how APOE genotypes affect brain metabolome changes with aging in mice, finding that APOE2 genotype is associated with better mitochondrial function and BCAA utilization.

Complex patterns of multimorbidity associated with severe COVID-19 and Long COVID

The paper identifies 679 diseases associated with increased risk for severe COVID-19 and Long COVID using UK Biobank health records, highlighting complex multimorbidity patterns and genetic risk loci.

Path-based reasoning in biomedical knowledge graphs with BioPathNet

BioPathNet improves link prediction in biomedical knowledge graphs by using path-based reasoning, outperforming existing methods and identifying novel drug indications and gene interactions.

Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease

The paper identifies sex-specific metabolomic differences in serum and brain of Alzheimer's disease mouse models, showing model-specific metabolic signatures that align with human APOE4 carriers.

Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants

The paper maps genetic associations with plasma proteins in 54,306 UK Biobank participants, identifying 10,248 new protein quantitative trait loci (pQTLs) and expanding the genetic architecture of the plasma proteome.

The landscape of metabolic brain alterations in Alzheimer's disease

This study identifies widespread metabolic dysregulation in Alzheimer's disease brain tissue, linking it to tau pathology and highlighting potential pathomechanisms.

Comprehensive genetic analysis of the human lipidome identifies novel loci controlling lipid homeostasis with links to coronary artery disease

This study identifies 667 genetic loci associated with lipid species and links 186 of them to coronary artery disease through integrative lipidomics and genomics.

Conserved cell-type specific signature of resilience to Alzheimer's disease nominates role for excitatory intratelencephalic cortical neurons

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature

The paper links indoxyl sulfate, a gut microbiome-derived metabolite, to anxiety symptoms and specific brain connectivity patterns in patients with depression.

Alterations in Acylcarnitines, Amines, and Lipids Inform about Mechanism of Action of Citalopram/Escitalopram in Major Depression

The paper uses targeted metabolomics to analyze changes in acylcarnitines, amines, and lipids in response to citalopram/escitalopram treatment in MDD patients, identifying metabolic correlates of treatment response.

Serum Metabolites Associate with Brain Amyloid Beta Deposition, Cognitive Dysfunction, and Alzheimers Disease Progression

The paper identifies serum metabolites associated with brain amyloid-beta deposition, cognitive dysfunction, and progression to Alzheimer's disease.

Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

This paper performs a large-scale eQTL meta-analysis across cerebral cortical and cerebellar brain regions, identifying distinct eQTL patterns and demonstrating improved power over existing studies.

The Alzheimer’s Disease Metabolome: Effects of Sex and APOE ε4 genotype

The paper investigates sex and APOE ε4 genotype effects on metabolic alterations in Alzheimer’s disease using stratified analysis of serum metabolites.

Peripheral Serum Metabolomic Profiles InformAntecedent Central Cognitive Impairment in Older Adults

This study identifies metabolites and pathways in serum and brain tissue associated with cognitive impairment and develops models to predict antecedent cognitive decline in older adults.

Identifying differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease using metabolic networks of human brain regions

The paper identifies differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease by analyzing transcriptomes and metabolomics data from brain samples.

Serum triglycerides in Alzheimer’s disease: Relation to neuroimaging and CSF biomarkers

The paper investigates the association between triglyceride principal component scores and Alzheimer's disease biomarkers in the ADNI cohort, finding significant links with MCI, AD, and specific brain structures.

Sets of Co-regulated Serum Lipids are Associated with Alzheimer Disease Pathophysiology

The paper identifies lipid sets in blood associated with Alzheimer's disease biomarkers and clinical symptoms using lipidomic profiling in the ADNI1 cohort.

Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome

The paper identifies altered bile acid profiles in Alzheimer's disease, linking them to cognitive impairment and genetic variants through a large study.

Altered Bile Acid Profile in Mild Cognitive Impairment and Alzheimer’s Disease: Relationship to Neuroimaging and CSF Biomarkers

The paper identifies associations between serum bile acid metabolites and AD biomarkers in the A/T/N framework, suggesting a potential role for bile acid pathways in AD pathophysiology.

Connecting genetic risk to disease endpoints through the human blood plasma proteome

The paper performs a GWAS on blood plasma proteome data from two cohorts to identify SNP-protein associations linked to various diseases and creates a genome-proteome network and web tool for analysis.