Histone lysine demethylase inhibition is a disease-modifying therapy for hypertrophic cardiomyopathy
Manjeet Singh, Yan Fan, Damir Alzhanov, Lingling Duan, Tram Ahn Tran, Dinesh Ravindra Raju, Jinhua Wen, Christian López, Matthias Peltz, Pietro Bajona, xing chao, Jun Liao, Dian J. Cao, Eric N. Olson, Elisabeth D. Martínez, Zhi‐Ping Liu
This study shows that inhibiting histone lysine demethylases with JIB-04 prevents and reverses hypertrophic cardiomyopathy through epigenetic changes.
bioRxiv · Aug 17, 2026 · PreprintPhysiology