This study shows that inhibiting histone lysine demethylases with JIB-04 prevents and reverses hypertrophic cardiomyopathy through epigenetic changes.

bioRxiv · Aug 17, 2026 · PreprintPhysiology

Coronary Artery Disease Transcriptomics Reveals Two Drivers of the Endothelial Cell SR-BI Expression and LDL Transport that Underlie Atherosclerosis

Linzhang Huang, Yibin Huang, Jiayu Zhu, Jun Peng, Kenian Chen, Ken L. Chambliss, Qinbo Zhou, Ryan J. Vela, DENNIS BURNS, Bo Li, Matthias Peltz, Yun Hua Fang, Lin Xu, Chieko Mineo, Philip W. Shaul

This study identifies two factors, hypercholesterolemia and disturbed blood flow, that upregulate endothelial SR-BI to drive LDL transport and atherosclerosis.

bioRxiv · Aug 6, 2026 · PreprintCell Biology

Maintenance of pig brain function under extracorporeal pulsatile circulatory control (EPCC)

Muhammed Shariff, Aksharkumar Dobariya, Obada Albaghdadi, Jacob Awkal, Hala Moussa, Gabriel Reyes, Mansur Syed, Robert G. Hart, Cameron Longfellow, Debra S. Douglass, Tarek Youssef El Ahmadieh, Levi B. Good, Vikram Jakkamsetti, Gauri Kathote, Gustavo Angulo, , Juan M. Pascual

This study develops a method to maintain pig brain function under extracorporeal pulsatile circulatory control, preserving neural activity and hemodynamics.

Scientific Reports · Aug 25, 2023Peer-reviewedNeuroscience