Formyl-peptide receptor type 2 activation mitigates secondary organ damage in inflammatory arthritis
Andreas Margraf, Jianmin Chen, Marilena Christoforou, Pol Claria-Ribas, Ayda Henriques Schneider, Chiara Cecconello, Wei Bu, Paul R. C. Imbert, Thomas D Wright, Stefan Russo, Isobel Alice Blacksell, Duco Steven Koenis, Jesmond Dalli, John A. Lupisella, Nicholas R. Wurtz, , Mauro Perretti
This study shows that activating FPR2 with a small molecule agonist reduces cardiac and lung damage in arthritic mice by decreasing inflammation and fibrosis.
bioRxiv · Feb 3, 2025 · PreprintPharmacology & Toxicology