The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization
Sarah Z. Hanif, CheukMan Cherie Au, Ingrid Torregroza, Caleb Kutz, Syeda Y. Jannath, Tabassum Fabiha, Bhavneet Bhinder, Michael P. Washburn, Dominic Devost, Shuchen Liu, Priya Bhardwaj, Todd Evans, Pradeep Kumar Anand, Robert Tarran, Sailesh Palikhe, , Kristy A. Brown
This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.
bioRxiv · Jul 22, 2024 · PreprintCancer Biology