Brca1 heterozygosity leads to hepatic steatosis in male and female mice despite sexually dimorphic effects on systemic metabolism
Sailesh Palikhe, Linlan Qiao, Caleb Kutz, Xiaobo Liang, Poojaben Dhorajiya, Devin C. Koestler, Priya Bhardwaj, Colin S. McCoin, Aditi Barnwal, Orion J. Peterson, Hubert Ming Tse, John P. Thyfault, Kristy A. Brown
This study shows that Brca1 heterozygosity causes hepatic steatosis in both male and female mice on a high-fat diet, despite sex differences in systemic metabolic outcomes.
Metabolism · Sep 2, 2026Peer-reviewedPhysiology