Cell BiologyNature CommunicationsPeer-reviewed
Hypoxia-induced metastatic heterogeneity in pancreatic cancer
Pradeep Moon Gunasekaran, Qianqian Wang, Polina Guseva…·Shin‐Heng Chiou
This study shows hypoxia promotes metastasis in pancreatic cancer by suppressing Kdm8, leading to epigenetic and transcriptomic changes, increased chromosomal instability, and metastatic disease.