Hypoxia-induced metastatic heterogeneity in pancreatic cancer
Pradeep Moon Gunasekaran, Qianqian Wang, Polina Guseva, Yoke‐Chen Chang, Rajika Chauhan, Alexander Kley, Mengdie Xu, Gene Lee, Gregory Marshall, Siddharth Ghosh Roy, Yousef Masoudpoor, Oscar Li, Arthur Roberts, Kelly Watkins Walton, Lucyann Franciosa, , Shin‐Heng Chiou
This study shows hypoxia promotes metastasis in pancreatic cancer by suppressing Kdm8, leading to epigenetic and transcriptomic changes, increased chromosomal instability, and metastatic disease.
Nature Communications · Jul 30, 2026Peer-reviewedCell Biology