BiochemistrybioRxivPreprint
In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.
Vini D. Meshram, Ramkumar Balaji, Preethi Saravanan…·Basant K. Patel
This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.
DOI 10.1101/2023.12.22.573011