Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.
Ramesh Kudira, Z. F. Yang, Immaculeta Osuji, Rebekah Karns, Priya Bariya, Liva Pfuhler, Mary Mullen, Amy Taylor, Hong Ji, Celine S Lages, Annika Yang vom Hofe, Tiffany Shi, Srikar Pasula, Joseph A Wayman, Anas Bernieh, , Alexander Gerhard Miethke
This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.
bioRxiv · May 17, 2024 · PreprintImmunology