Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.
Ramesh Kudira, Z. F. Yang, Immaculeta Osuji, Rebekah A. Karns, Priya Bariya, Liva Pfuhler, Mary M. Mullen, Amy E. Taylor, Hongjian Ji, Celine Silva Lages, Annika Yang vom Hofe, Tiffany Shi, Srikar Pasula, Joseph A. Wayman, Anas Bernieh, , Alexander Gerhard Miethke
This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.
bioRxiv · May 17, 2024 · PreprintImmunology