A VHL-1/HIF-1/SQRD1/COL-88 axis links extracellular matrix formation with longevity in Caenorhabditis elegans
Willian Goulart Salgueiro, Reza Esmaillie, Katrin Bohl, Cyril Statzer, Puneet Bharill, Sebastian Bargfrede, Manopriya Chokkalingam, Maike Neutzer, Michael Ignarski, Thomas R. Benzing, Andreas Beyer, Bernhard Schermer, Collin Y. Ewald, Francesca Fabretti, Roman‐Ulrich Müller
This paper identifies a VHL-1/HIF-1/SQRD-1/COL-88 axis linking extracellular matrix formation with longevity in C. elegans, showing that loss of VHL-1 increases lifespan and alters collagen expression.
bioRxiv · Feb 22, 2024 · PreprintGenetics