Cyril Statzer

A VHL-1/HIF-1/SQRD1/COL-88 axis links extracellular matrix formation with longevity in Caenorhabditis elegans

This paper identifies a VHL-1/HIF-1/SQRD-1/COL-88 axis linking extracellular matrix formation with longevity in C. elegans, showing that loss of VHL-1 increases lifespan and alters collagen expression.

Mechanotransduction coordinates extracellular matrix protein homeostasis promoting longevity in C. elegans

The paper identifies hemidesmosome-containing structures that mediate mechanotransduction to regulate ECM homeostasis and promote longevity in C. elegans.

Condensin I folds the C. elegans genome

This study shows that condensin I/IDC, not cohesin, is the major genome loop extruder in C. elegans, leading to genome decompaction and loss of TAD structures.

Longevity interventions temporally scale healthspan in Caenorhabditis elegans

This study shows that longevity interventions in C. elegans temporally scale healthspan rather than compress sickspan, suggesting similar mechanisms may apply in mammals.

Multi-Omic Profiling of the Liver Across Diets and Age in a Diverse Mouse Population

The paper uses multi-omics data from mice to identify gene-environment-age interactions and causal molecular networks linked to longevity.

The extracellular matrix phenome across species

The paper defines extracellular matrix phenomes across species by analyzing genotype-to-phenotype relationships and identifies key genes and phenotypes associated with matrisome variations.