GeneticsbioRxivPreprint
A VHL-1/HIF-1/SQRD1/COL-88 axis links extracellular matrix formation with longevity in Caenorhabditis elegans
Willian Goulart Salgueiro, Reza Esmaillie, Katrin Bohl…·Roman‐Ulrich Müller
This paper identifies a VHL-1/HIF-1/SQRD-1/COL-88 axis linking extracellular matrix formation with longevity in C. elegans, showing that loss of VHL-1 increases lifespan and alters collagen expression.
DOI 10.1101/2024.02.22.581513