E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial Hypertension
Dan Yi, Ankit Tripathi, Q Zheng, Bin Liu, S Cao, Jeffrey R. Koenitzer, Mengcheng Shen, Michael B. Fallon, Zhiyu Dai
This study identifies E2F1 as a driver of pulmonary arterial hypertension by linking endothelial cell-cycle activation to arterial programming and vascular remodeling, showing that its inhibition mitigates disease in models.
bioRxiv · Jul 7, 2026 · PreprintPhysiology