Ankit Tripathi

This study identifies E2F1 as a driver of pulmonary arterial hypertension by linking endothelial cell-cycle activation to arterial programming and vascular remodeling, showing that its inhibition mitigates disease in models.

The paper identifies FABP4/5 as key regulators of endothelial glycolysis and arterial programming in pulmonary hypertension using single-cell and spatial transcriptomics.