Zhiyu Dai

RAPPL-Seq Enables Rapid, High-Sensitivity Ribosome Profiling of Scarce Samples

RAPPL-Seq enables rapid, high-sensitivity ribosome profiling of scarce samples by improving RPF recovery efficiency and reducing processing time.

Sexually dimorphic role of estrogen receptor α in preserving right ventricular endothelial integrity

This study shows estrogen receptor α protects female RV endothelial cells from apoptosis and supports angiogenesis in pulmonary hypertension, revealing a sex-specific role in RV function.

CD133+ progenitor cells promote pulmonary hypertension through CXCR4 signaling

This study identifies CD133+ progenitor cells as contributors to pulmonary hypertension and shows that CXCR4 signaling drives their pathogenic role in vascular remodeling.

E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial Hypertension

This study identifies E2F1 as a driver of pulmonary arterial hypertension by linking endothelial cell-cycle activation to arterial programming and vascular remodeling, showing that its inhibition mitigates disease in models.

LOSS OF ROR2 TYROSINE KINASE RECEPTOR IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN PAH VIA INAPPROPRIATE INTEGRIN BETA 1 ACTIVATION

This study shows that loss of ROR2 leads to endothelial dysfunction in PAH through inappropriate integrin beta 1 activation, impairing barrier integrity and angiogenesis.

Molecular Imaging of the TGF-β Activating Integrin αvβ6 Detects Chronic Lung Allograft Dysfunction

The paper uses molecular imaging to detect chronic lung allograft dysfunction by targeting the TGF-β-activating integrin αvβ6 in mouse and human lung transplants.

The Liver is an Inflammatory Mediator of Pulmonary Arterial Hypertension

This study identifies subclinical liver dysfunction clusters in PAH patients and links them to pulmonary vascular resistance and immune signaling changes.

Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

The paper identifies FABP4/5 as key regulators of endothelial glycolysis and arterial programming in pulmonary hypertension using single-cell and spatial transcriptomics.

EBF1 controls an embryonic artery-forming niche that reactivates in pulmonary arterial hypertension

This study identifies EBF1 as a regulator of embryonic artery formation and shows its reactivation in pulmonary arterial hypertension drives pathological vascular remodeling.