Mengcheng Shen

This study identifies E2F1 as a driver of pulmonary arterial hypertension by linking endothelial cell-cycle activation to arterial programming and vascular remodeling, showing that its inhibition mitigates disease in models.

The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.

This study demonstrates an efficient chemical method to generate iPSCs from frozen umbilical cord tissue, highlighting its safety and potential for regenerative medicine.

This study uses single-cell chromatin accessibility analysis to identify developmental trajectories and non-coding mutations associated with congenital heart disease.