COMT inhibitor tolcapone represses the migration and invasion of trophoblast and results in preeclampsia-like phenotypes in mice
L. Chen, Y. Li, M. Pang, Q. Jie, F. Sun, L. Huang, Y. Ma, F. Wu, X. Yue
This study shows that tolcapone causes embryo lethality and preeclampsia-like phenotypes in mice by inhibiting trophoblast migration and invasion.
bioRxiv · Mar 17, 2023 · PreprintPharmacology & Toxicology