CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B1 cells in the bone marrow
S. Elias, R. Sharma, M. Schizas, I. Valdez, S.-M. Park, P. Gonzalez-Figueroa, Q.-Z. Li, B. Hoyos, A. Y. Rudensky
This study shows that CXCR4+ Treg cells regulate B1 cell accumulation in the bone marrow, leading to control of IgM autoantibody production and serum IgM levels.
bioRxiv · Nov 14, 2021Immunology