A. Y. Rudensky

This study identifies butyrate, a microbiota-derived metabolite, as a regulator of peripheral efferocytosis, showing its ability to restore impaired phagocytic clearance in antibiotic-treated mice.

The paper identifies a terminal differentiated subset of colonic effector Treg cells that express IL-10 and is essential for preventing intestinal inflammation.

The paper identifies six distinct synovial fibroblast states in RA driven by cytokine exposure and shows similarities to fibroblast states in other tissues.

This study identifies a new RORγt+ antigen-presenting cell type, Thetis cells, that drives microbiota-dependent regulatory T cell differentiation and tolerance during early life.

This study shows that CXCR4+ Treg cells regulate B1 cell accumulation in the bone marrow, leading to control of IgM autoantibody production and serum IgM levels.

The paper maps immune cell phenotypes in breast cancer using single-cell RNA-seq and identifies continuous tumor-specific expansions driven by environmental cues.