Mitochondrial Fission Regulates Transcription of Ribosomal Protein Genes in Embryonic Hearts
Qiancong Zhao, Shun Yan, Jin Ying Lu, Danitra J. Parker, Huiying Wu, Qianchuang Sun, David K. Crossman, Shanrun Liu, Qin Wang, Hiromi Sesaki, Kasturi Mitra, Kexiang Liu, Kai Jiao
This study shows that mitochondrial fission is essential for embryonic heart development by regulating ribosomal protein gene transcription through an AMPK-SIRT7-GABPB axis.
bioRxiv · Feb 10, 2021 · PreprintDevelopmental Biology