Shanrun Liu

This study uses human iPSC-derived skin organoids to model fibrosis, identifies RUNX2 as a key driver, and finds a small molecule that suppresses fibrotic programs.

The paper characterizes the evolutionary origin and expression of MAEL in the developing human brain and finds reduced MAEL expression in hydrocephalus brain tissue.

This study uses endoluminal tissue sampling to analyze genetic and transcriptional features of vein of Galen malformation endothelial cells.

The paper shows that DICER1 activity is essential for mitral valve development but not tricuspid valve development, revealing miRNA-mediated gene regulation as a differential mechanism.

This study shows that mitochondrial fission is essential for embryonic heart development by regulating ribosomal protein gene transcription through an AMPK-SIRT7-GABPB axis.

The paper uses single-cell and bulk RNA-seq to analyze gene expression changes in human retina with AMD, identifying cell type-specific alterations.