Chemical Proteomic Profiling of the Histaminylation Proteome in Cancer Cells Unveils Uncharted Epigenetic Marks on Core Histones
Xingyu Ma, Anne A Leaman, Lin Zeng, Huapeng Li, Zhengjun Cai, Qianyue Wang, Kaiwaan Dalal, Md Shahadat Hossain, Venkatesh P. Thirumalaikumar, Zhihong Wang, Valerie P. O’Brien, W. Andy Tao, Qingfei Zheng
This study identifies new TGM2-catalyzed histaminylation marks on core histones in cancer cells and reveals their crosstalk with γH2AX formation in DNA damage responses.
Journal of the American Chemical Society · Aug 3, 2026Peer-reviewedBiochemistry