Lin Zeng

Chemoselective Bioconjugation Reveals Norepinephrinylation (NEylation) as a Widespread Post-Translational Modification in Cells

The paper develops a chemoselective bioconjugation method to detect and analyze NEylation, revealing it as a widespread PTM affecting protein function in cells.

Chemical Proteomic Profiling of the Histaminylation Proteome in Cancer Cells Unveils Uncharted Epigenetic Marks on Core Histones

This study identifies new TGM2-catalyzed histaminylation marks on core histones in cancer cells and reveals their crosstalk with γH2AX formation in DNA damage responses.

FRUCTOSE ACTIVATES A STRESS RESPONSE SHARED BY METHYLGLYOXAL AND HYDROGEN PEROXIDE IN STREPTOCOCCUS MUTANS

This paper shows fructose activates a stress response in Streptococcus mutans similar to methylglyoxal and hydrogen peroxide, affecting gene expression and bacterial competitiveness.

Regioselective Rapid Ene-type Reaction (RRER) Enables Bioconjugation of Histone Serotonylation

This study introduces a pH-controlled regioselective rapid ene-type reaction (RRER) for selectively modifying histone H3Q5 serotonylation and measuring its levels in cells and tissues.

Systematic Analysis of the Glucose-PTS in Streptococcus sanguinis Highlighted its Importance in Central Metabolism and Bacterial Fitness

This study investigates the role of the glucose-PTS in Streptococcus sanguinis, showing its impact on bacterial fitness, acid production, and antagonism against S. mutans.

Glycerol Metabolism Contributes to Competition by Oral Streptococci through Production of Hydrogen Peroxide

This study shows that glycerol metabolism in oral commensal streptococci produces hydrogen peroxide, enhancing competition against the pathogen Streptococcus mutans.