Cancer BiologyNature CommunicationsPeer-reviewed
De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
Huan Zhang, Naiara Santana-Codina, Qijia Yu…·Joseph Douglas Mancias
This study identifies that combining DHODH inhibition with BCL-XL targeting synergistically induces apoptosis in pancreatic cancer, offering a new combination therapy strategy.
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