NDNF+ interneurons have a privileged role in regulating cortical excitability
Amy Richardson, Marion S. Mercier, Yoshiteru Shimoda, R. Graham, Marco Leite, Alejandro J. Garcia, Maud Muller, Suraya A Bond, Maria Grodzdanova, Qimin Wu, Andreas Lieb, Dimitri Michael Kullmann, Vincent Magloire
This study shows NDNF+ interneurons regulate cortical excitability, with depolarization suppressing seizures and hyperpolarization exacerbating them, mediated by GABAB receptors.
bioRxiv · Nov 27, 2025 · PreprintNeuroscience