Vincent Magloire

This study shows NDNF+ interneurons regulate cortical excitability, with depolarization suppressing seizures and hyperpolarization exacerbating them, mediated by GABAB receptors.

This paper evaluates gene therapy using Kv1.1 potassium channel overexpression in a mouse model of FCD, showing reduced seizures but no improvement in cognitive or behavioral issues.

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

This study shows that theta-burst activity in entorhinal cortex afferents induces Hebbian LTP in neurogliaform interneurons, increasing disynaptic inhibition of CA1 pyramidal neurons and shifting excitation-inhibition balance.

This study shows that dendritic NMDA receptors in parvalbumin neurons enable cooperative recruitment of interneurons, strengthening and stabilizing principal cell assemblies.

This paper develops a genetically encoded fluorescent sensor, iGABASnFR, to monitor GABA in vivo and demonstrates its use in tracking GABA dynamics in various neural contexts.

This study shows that overexpressing KCC2 in principal neurons prevents PV+ interneurons from promoting seizures during seizure onset.