Dimitri Michael Kullmann

NDNF+ interneurons have a privileged role in regulating cortical excitability

This study shows NDNF+ interneurons regulate cortical excitability, with depolarization suppressing seizures and hyperpolarization exacerbating them, mediated by GABAB receptors.

Coincidence detection in aspiny interneuron dendrites

The paper investigates supralinear synaptic integration in neurogliaform interneurons and shows that coincident synaptic inputs and backpropagating action potentials enhance dendritic depolarization and calcium influx.

An adaptable, reusable, and light implant for chronic Neuropixels probes

The paper introduces an adaptable implant for chronic Neuropixels recordings in mice, enabling stable, reusable, and lightweight neural recordings across multiple experimental conditions.

Supralinear dendritic integration in murine dendrite-targeting interneurons

The paper demonstrates supralinear dendritic integration in specific inhibitory hippocampal interneurons using electrophysiology and imaging techniques.

Anti-seizure Gene Therapy for Focal Cortical Dysplasia

This paper evaluates gene therapy using Kv1.1 potassium channel overexpression in a mouse model of FCD, showing reduced seizures but no improvement in cognitive or behavioral issues.

Extracellular glutamate and GABA transients at the transition from interictal spiking to seizures

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.

Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

Developmental instability of CA1 pyramidal cells in Dravet Syndrome

This study investigates how loss of Scn1a affects CA1 pyramidal cell development and homeostatic plasticity in a Dravet Syndrome model before seizures occur.

Long-term potentiation in neurogliaform cells modulates excitation-inhibition balance in the temporoammonic pathway

This study shows that theta-burst activity in entorhinal cortex afferents induces Hebbian LTP in neurogliaform interneurons, increasing disynaptic inhibition of CA1 pyramidal neurons and shifting excitation-inhibition balance.

A knock-in Drosophila model supports a conserved link between potassium channelopathy and involuntary movement

This study creates a Drosophila model with a hSlo1 D434G mutation, showing motor dysfunction and altered action potentials linked to BK channel gain-of-function.

Learning to live with Dale's principle: ANNs with separate excitatory and inhibitory units

Splitting network units into excitatory and inhibitory populations need not cost learning: initialize inhibition to centre and standardize excitatory activity, and scale inhibitory updates by Fisher information.

Alternative splicing tunes sodium channels to support channel- and neuron- specific effects

The paper shows that alternative splicing of sodium channels Nav1.1 and Nav1.2 has cell-type-specific effects on neuronal activity and firing properties.

In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

This study uses CRISPRa to increase Kv1.1 expression in mouse hippocampal neurons, reducing seizures and cognitive deficits in a temporal lobe epilepsy model.

Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies

This study shows that dendritic NMDA receptors in parvalbumin neurons enable cooperative recruitment of interneurons, strengthening and stabilizing principal cell assemblies.

A genetically encoded fluorescent sensor for in vivo imaging of GABA

This paper develops a genetically encoded fluorescent sensor, iGABASnFR, to monitor GABA in vivo and demonstrates its use in tracking GABA dynamics in various neural contexts.

Olanzapine: a full and potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

The paper identifies olanzapine as a potent and full agonist for the hM4D(Gi) DREADD, enabling clinical translation of chemogenetics for CNS diseases.

KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition

This study shows that overexpressing KCC2 in principal neurons prevents PV+ interneurons from promoting seizures during seizure onset.

Epilepsy gene therapy using non-integrating lentiviral delivery of an engineered potassium channel gene

This paper develops a non-integrating lentiviral gene therapy for refractory focal epilepsy, showing reduced seizure frequency in a rat model.

Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities

This study shows that loss of Frrs1l in mice causes reduced synaptic AMPA receptor levels, leading to motor, cognitive, and electrographical abnormalities.

Analog closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude

This study uses closed-loop optogenetic modulation to show that gamma frequency and amplitude in hippocampal pyramidal cells can be independently altered by adjusting feedback timing.

Semiology, clustering, periodicity and natural history of seizures in an experimental visual cortical epilepsy model

This paper characterizes a rat model of focal neocortical epilepsy induced by tetanus toxin injection, showing seizure clustering, circadian variation, and predictive seizure counts.

Mutations In Membrin/GOSR2 Reveal Stringent Secretory Pathway Demands Of Dendritic Growth And Synaptic Integrity

This study investigates how mutations in Membrin/GOSR2 affect dendritic growth and synaptic integrity in Drosophila models, revealing their role in neurological disorders.

Mitochondrial impairment and rescue in riboflavin responsive neuropathy

This study identifies RFVT gene mutations in BVVLS, shows mitochondrial dysfunction, and demonstrates therapeutic potential with riboflavin esters.

Focal cortical seizures start as standing waves and propagate respecting homotopic connectivity

This study shows that focal seizures in mice start as standing waves in V1 and propagate following homotopic connectivity patterns similar to normal visual processing.