R. Graham

NDNF+ interneurons have a privileged role in regulating cortical excitability

This study shows NDNF+ interneurons regulate cortical excitability, with depolarization suppressing seizures and hyperpolarization exacerbating them, mediated by GABAB receptors.

Anti-seizure Gene Therapy for Focal Cortical Dysplasia

This paper evaluates gene therapy using Kv1.1 potassium channel overexpression in a mouse model of FCD, showing reduced seizures but no improvement in cognitive or behavioral issues.

Extracellular glutamate and GABA transients at the transition from interictal spiking to seizures

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.

Circadian rhythm in cortical chloride homeostasis underpins variation in network excitability

The paper shows that intracellular chloride levels in cortical pyramidal cells vary diurnally, affecting neuronal network stability and seizure latency.

Synergistic positive feedback underlying seizure initiation

The paper identifies synergistic positive feedback mechanisms that drive seizure initiation and shows that an optogenetic stimulation paradigm can delay epileptic activity.

Divergent paths to seizure-like events.

The paper compares two in vitro models of epileptic seizures, finding differences in glutamatergic involvement and seizure-like event characteristics.