Marco Leite

This study shows NDNF+ interneurons regulate cortical excitability, with depolarization suppressing seizures and hyperpolarization exacerbating them, mediated by GABAB receptors.

This paper evaluates gene therapy using Kv1.1 potassium channel overexpression in a mouse model of FCD, showing reduced seizures but no improvement in cognitive or behavioral issues.

The paper uses fluorescent sensors to study glutamate and GABA dynamics during interictal spikes and seizures in a rodent model, revealing a progressive failure of inhibitory restraint leading to seizures.

Splitting network units into excitatory and inhibitory populations need not cost learning: initialize inhibition to centre and standardize excitatory activity, and scale inhibitory updates by Fisher information.

This study shows that reducing LGI1 levels increases neuronal excitability and synaptic plasticity, potentially contributing to epilepsy and limbic encephalitis.

This study shows that dendritic NMDA receptors in parvalbumin neurons enable cooperative recruitment of interneurons, strengthening and stabilizing principal cell assemblies.

This paper develops a genetically encoded fluorescent sensor, iGABASnFR, to monitor GABA in vivo and demonstrates its use in tracking GABA dynamics in various neural contexts.

This study uses closed-loop optogenetic modulation to show that gamma frequency and amplitude in hippocampal pyramidal cells can be independently altered by adjusting feedback timing.

This paper characterizes a rat model of focal neocortical epilepsy induced by tetanus toxin injection, showing seizure clustering, circadian variation, and predictive seizure counts.