Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance
Jianyong Liu, Qing-Li He, Jianya Zhou, Ajay M. Vaghasia, Roshan Chikarmane, Glenn Hauk, Archana Rachakonda, Nicole Castagna, Ruchama C. Steinberg, Minh-Tam Pham, Jordan M. Gregg, Alok Mishra, Yuhan Yang, Talha Anwar, Roy Elias, , Srinivasan Yegnasubramanian
This paper identifies triptolide as a compound that enhances the effectiveness of DNMTi by inhibiting DCTPP1, overcoming resistance in cancer cells.
bioRxiv · May 19, 2024Cancer Biology