TFAP2A+ embryonic progenitor cells undergo fate diversification to give rise to human amnion, germline, and mesoderm
Auriana Arabpour, Jonathan DiRusso, Qiu Ya Wu, Mark Larsen, Young Sun Hwang, Elsie C. Jacobson, Thi Xuan Ai Pham, Nicole Agranonik, Megan Sparrow, Vernon Monteiro, Zenya Rebecca Bian, Nicolás Peláez, Antuca Callejas-Marín, Vincent Pasque, Kathrin Plath, Amander T. Clark
The paper shows that TFAP2A+ progenitor cells generate amnion, germline, and mesoderm through BMP signaling and basement membrane cues in vitro.
bioRxiv · Jun 26, 2025 · PreprintDevelopmental Biology