Author

Thi Xuan Ai Pham

Leuven Stem Cell InstituteORCID 0000-0003-3866-2002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:development & morphogenesis· 1 Research Focus:spatial domain detection· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Vincent PasqueiD· 4 shared Sherif KhodeeriD· 2 shared Alejandro Aguilera-CastrejoniD· 1 shared Amander T. ClarkiD· 1 shared Amitesh PandaiD· 1 shared Andrea Drusin· 1 shared Anna OsnatoiD· 1 shared Anne WenzeliD· 1 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersDevelopmental Biology

Vincent PasqueORCID

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4 papers

Recent·Most cited

XIST Drives X-Chromosome Inactivation and Safeguards Female Extraembryonic Cells in Humans

Amitesh Panda, Leo Carrillo, Bradley Philip Balaton, Jeanne Brouillet, Solomon Nshemereirwe, Jarne Bonroy, Charbel Alfeghaly, Romina Facchinello, Sherif Khodeer, Ruben Boers, Gaël Castel, Charlie London, Emmanuel Cazottes, Madeleine Moscatelli, Raissa Songwa Tchinda, , Vincent Pasque

This study shows that XIST is required for XCI in human extraembryonic cells, which is essential for their survival and development.

bioRxiv · Nov 19, 2025 · PreprintDevelopmental Biology

TFAP2A+ embryonic progenitor cells undergo fate diversification to give rise to human amnion, germline, and mesoderm

Auriana Arabpour, Jonathan DiRusso, Qiu Ya Wu, Mark Larsen, Young Sun Hwang, Elsie C. Jacobson, Thi Xuan Ai Pham, Nicole Agranonik, Megan Sparrow, Vernon Monteiro, Zenya Rebecca Bian, Nicolás Peláez, Antuca Callejas-Marín, Vincent Pasque, Kathrin Plath, Amander T. Clark

The paper shows that TFAP2A+ progenitor cells generate amnion, germline, and mesoderm through BMP signaling and basement membrane cues in vitro.

bioRxiv · Jun 26, 2025 · PreprintDevelopmental Biology

Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential

Giada Rossignoli, Michael Oberhuemer, Ida Sophie Brun, Irene Zorzan, Anna Osnato, Anne Wenzel, Emiel van Genderen, Andrea Drusin, Giorgia Panebianco, Nicolo Magri, Mairim Alexandra Solís, Chiara Colantuono, Sam Samuel Franciscus Allegonda van Knippenberg, Thi Xuan Ai Pham, Sherif Khodeer, , Graziano Martello

This study develops a feeder-free serum-coated system for culturing naive human pluripotent stem cells, maintaining their developmental potential and reducing contamination and mutations.

bioRxiv · Jan 17, 2025 · PreprintCell Biology

Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naive PSCs

Bernardo Oldak, Emilie Wildschutz, Vladyslav Bondarenko, Mehmet-Yunus Comar, Cheng Zhao, Alejandro Aguilera-Castrejon, Shadi Tarazi, Sergey V. Viukov, Thi Xuan Ai Pham, Shahd Ashouokhi, Dmitry Lokshtanov, Francesco Roncato, E. Feldstein Ariel, Max Rose, Nir Livnat, , Jacob H. Hanna

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

Nature · Sep 6, 2023Peer-reviewedDevelopmental Biology