Actions of the Anti-Seizure Drug Carbamazepine in the Thalamic Reticular Nucleus: Potential Mechanism of Aggravating Absence Seizures
Sung-Soo Jang, Nicole Agranonik, John R. Huguenard
This study investigates how carbamazepine (CBZ) affects thalamic reticular neurons, revealing it selectively inhibits their tonic firing and disrupts GABAergic transmission, which exacerbates absence seizures.
Proceedings of the National Academy of Sciences · Jul 31, 2025Peer-reviewedPhysiology