PDE3A2 modRNA Fine-Tunes Nuclear cAMP Microdomains and Reverses Pathological Cardiac Hypertrophy
Wenjing Xiang, Mingwei Lian, Qiuyun Guan, Xingsheng Sun, Supeng Li, Haocheng Lu, Gangjian Qin, Yang K. Xiang, Haibo Ni, Ying Wang
This study develops PDE3A2-modRNA to restore nuclear cAMP microdomain regulation, reversing pathological cardiac hypertrophy in a mouse model.
bioRxiv · Sep 30, 2025 · PreprintPathology